Table 2.

ANRIL-Regulated Genes

Gene	Mode	Gene description	Tissue / cell type	Disease	Ref.
ANRIL	cis	ANRIL, long ncRNA	PBMC, atherosclerotic plaque	CAD, PD	(39)
CDKN2A	cis	Cyclin-dependent kinase Inhibitor 2A, tumor suppressor	ANRIL knock-down in VSMC	Cancer	(45)
CDKN2B	cis	Cyclin-dependent kinase Inhibitor 2B, tumor suppressor	ANRIL knock-down in VSMC	Cancer	(45)
ADIPOR1	trans	Adiponectin receptor 1, glucose, lipid metabolism	inducible ANRIL knock-down in T-Rex 293 HEK cells	Diabetes, CVD	(13)
VAMP3	trans	Vesicle-associated membrane protein 3,IL-6, TNFα secretion	inducible ANRIL knock-down in T-Rex 293 HEK cells	Inflammation / cancer	(13)
C11ORF10	trans	TMEM258,N-glycosylation	inducible ANRIL knock-down in T-Rex 293 HEK cells	Unknown	(13)
DUT	trans	Deoxyuridine Triphosphatase, nucleotide metabolism	Transformed B cells	Unknown	(55)
EIF1AY	trans	Eukaryotic translation initiation factor 1A (Y-chr.), mRNA Translation	Transformed B cells	Unknown	(55)
CASP14	trans	Caspase-14,Inflammation, apoptosis	Transformed B cells	Psoriasis	(55)
ABCA1	trans	ATP binding cassette transporter A1, sterol transport	Transformed B cells	CAD/MI	(55)
DHRS9	trans	Dehydrogenase reductase 9, retinol metabolism	Transformed B cells	Unknown	(55)
CARD8	trans	Caspase recruitment domain 8, inflammasome	ANRIL knock-down / over-expression in HUVEC, HepG2 cells	Inflammation	(61)

CAD, coronary artery disease; CVD, cardiovascular disease; HUVEC, human umbilical vein endothelial cells; IL, interleukin; PBMC, peripheral blood mononuclear cells; VSMC, vascular smooth muscle cells