Table 8.
Results for redistributing treatment effects on NPI subscales
| Base case | 3 points on depression | 3 points on anxiety | 3 points on irritability | 3 points on sleep disorder | |
|---|---|---|---|---|---|
| ICER, USD | 344,425 | 384,656 | 401,152 | 398,010 | 501,946 |
| Cost outcomes, USD | |||||
| Care cost | (9,308) | (8,202) | (7,815) | (7,868) | (3,923) |
| Health outcomes | |||||
| Patient QALYs | 0.045 | 0.043 | 0.042 | 0.042 | 0.041 |
| Caregiver QALYs | 0.01 | 0.008 | 0.007 | 0.009 | 0 |
| Psychiatric medication use | |||||
| Time on psychiatric medication | (0.24) | (0.25) | (0.21) | (0.005) | (0.005) |
| Time on antipsychotics | (0.002) | (0.002) | (0.002) | (0.002) | (0.002) |
| Time on antidepressants | (0.19) | (0.25) | (0.002) | (0.002) | (0.002) |
| Time on anxiolytics | (0.05) | (0.002) | (0.26) | (0.002) | (0.002) |
| 1 point on depression, irritability and sleep disorder | 2 points on anxiety, 1 point on depression | 2 points on depression, 1 point on anxiety | 2 points on sleep disorder, 1 point on irritability | 2 points on irritability, 1 point on sleep disorder | |
|---|---|---|---|---|---|
| ICER, USD | 382,565 | 361,340 | 357,380 | 438,349 | 404,607 |
| Cost outcomes, USD Care cost | (7,603) | (8,841) | (8,943) | (5,723) | (7,022) |
| Health outcomes Patient QALYs | 0.045 | 0.04 | 0.04 | 0.04 | 0.04 |
| Caregiver QALYs | 0.007 | 0.008 | 0.01 | 0.004 | 0.007 |
| Psychiatric medication use, years | |||||
| Time on psychiatric medication | (0.19) | (0.39) | (0.28) | (0.005) | (0.005) |
| Time on antipsychotics | (0.002) | (0.002) | (0.002) | (0.002) | (0.002) |
| Time on antidepressants | (0.19) | (0.19) | (0.23) | (0.002) | (0.002) |
| Time on anxiolytics | (0.002) | (0.26) | (0.05) | (0.002) | (0.002) |
The reported results are differences between treatment and placebo arms. ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life-year.