Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 24;10:49. doi: 10.1186/s13195-018-0377-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — Global antibody distribution in the brain. Brain distribution in 18-month-old tg-ArcSwe mice given an injection with [¹²⁵I]RmAb158-scFv8D3 (a) and [¹²⁵I]RmAb158 (b), 6 days postinjection, as visualized with ex vivo autoradiography (left) in comparison with amyloid-β 40 immunostaining (right). Whereas [¹²⁵I]RmAb158-scFv8D3 was distributed throughout the whole brain, [¹²⁵I]RmAb158 was confined to central parts of the brain. For comparison, also wild-type animals were given an injection with [¹²⁵I]RmAb158-scFv8D3, resulting in no signal (c) and with [¹²⁵I]RmAb158, where a faint signal was detected centrally in the brain (d)