Fig. 2.

Pharmacokinetics and brain distribution. a Plasma pharmacokinetics of RmAb158-scFv8D3 (32 nmol/kg) and RmAb158 at two different doses (32 nmol/kg and 320 nmol/kg), expressed as the percentage of the injected dose (%ID) per gram of plasma. b Drug exposure calculated from the plasma AUC in (a). c Brain retention of antibodies expressed as %ID per gram of brain tissue. d Ratio of the antibodies’ retention in the brain to drug exposure displays their relative efficiency in entering and being retained in the brain