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. 2018 May 24;10:49. doi: 10.1186/s13195-018-0377-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Positron emission tomographic (PET) imaging after pretreatment (blocking) with PBS, RmAb158-scFv8D3, or RmAb158. a Sagittal view of PET images (standardized uptake value ratio [SUVR] normalized to the reference region, the cerebellum) obtained with [¹²⁴I]RmAb158-scFv8D3 administered to 18-month-old tg-ArcSwe mice 3 days after injection with PBS (n = 2), 32 nmol/kg RmAb158-scFv8D3 (n = 2), or 320 nmol/kg RmAb158 (n = 2). b Quantification of SUVR (ROI/cerebellum) from PET images in (a) for whole brain, hippocampus, thalamus, striatum, and cortex. Graph displays scatterplot with bars representing group mean and error bars for SD. * p < 0.05, ** p < 0.01, and *** p < 0.001 in comparison with the PBS group by two-way analysis of variance and Dunnett’s post hoc test