Table 5.

Minimum Hypothetical Relative Increase in Risk (HRI_Z → G) to Detect an Outbreak of Guillain-Barré Syndrome and Expected Observed Risk Ratios if the Risk if Zika Virus Infection Doubles During an Outbreak^a

Sensitivity/specificity (%) b	HRIZ → G in GBS riskc	Observed risk ratio
100/100	4	1.18
82.1/100	5	1.23
82.1/91.7	7	1.30
82.1/88.9	8	1.33
82.1/80.6	9	1.36

^a Corrected for non-differential misclassification due to a sensitivity of 82.1% and varying levels of specificity of the GBS case definition

^b A fixed level of sensitivity was obtained by averaging findings from studies assessing the validity of Brighton criteria in adults

^c HRI_Z → G: Minimum Hypothetical Relative Increase in Risk of Guillain-Barré síndrome