Table 2.
Distribution of HLA-DQ genotypes in patients with celiac disease and control
| HLA Genotype |
Patient (n = 49) | Control (n = 58) | Odds ratio | 95% CL | Relative risk | P-value | ||
|---|---|---|---|---|---|---|---|---|
| n | Fr (%) | n | Fr (%) | |||||
| DQ2.5/DQ8 | 5 | 10.2 | 1 | 1.7 | 6.48 | 0.73–57.46 | 1/10 | 0.09 |
| DQ2.5/DQ2.5 | 24 | 49 | 6 | 10.3 | 8.32 | 3.02–22.93 | 1/12.5 | < 0.01 |
| DQ2.5/DQ2.2 | 5 | 10.2 | 2 | 3.4 | 3.18 | 0.59–17.19 | 1/20 | 0.18 |
| DQ8/DQX | 4 | 8.2 | 2 | 3.4 | 2.49 | 0.44–14.21 | 1/25 | 0.31 |
| DQ2.5/DQ7 | 8 | 16.3 | 4 | 6.9 | 2.63 | 0.74–9.35 | 1/25 | 0.13 |
| DQ2.2/DQ8 | 1 | 2 | 1 | 1.7 | 1.19 | 0.07–19.92 | 1/50 | 0.90 |
| DQ2.2/DQ2.2 | 2 | 4.1 | 3 | 5.2 | 0.78 | 0.13–4.87 | 1/100 | 0.79 |
| DQ2.x | 0 | 0 | 4 | 6.9 | 0.12 | 0.01–2.33 | 0 | 0.16 |
| DQX/DQX | 0 | 0 | 35 | 60.3 | 0.01 | 0.00–0.11 | 0 | < 0.01 |
n number of the patients or the control, Fr frequency. Odds ratio and P-values have been calculated on the total data set comparing CD patients versus the control genotypes. Relative risk of developing disease for specific genotypes were calculated as a ratio of specific HLA-DQ genotype proportion in CD patients and control by taking into account the prevalence of the CD (0.016) in Syrian population