Fig. 1.

Schematic representation of CK1α. a CK1 family and CK1 superfamily. b Four isoforms of CK1α and their functional domains. c Cartoon representation of DNA damage-binding protein (DDB)1ΔBPB-CRBN-lenalidomide-CK1α. Top left, DDB1, CRBN, and CK1α domain color coding and boundaries. Bottom right, enlarged view of the CRBN-lenalidomide-CK1α interface (data were obtained from protein data bank: www.rcsb.org, PDB-ID: 5FQD; and were first published in reference [13]). d Investigations on CK1α in diverse research fields