Fig. 5.

Analysis of genetic factors contributing to dose-limiting irinotecan toxicity. a Scheme showing tissue specific involvement of gene products in the irinotecan pathway. See www.pharmgkb.org/pathway/PA2001 for further information. b Overview of the aggregated frequencies of common (MAF ≥ 1%, blue) and rare deleterious genetic variants (MAF < 1%, red) in genes implicated in irinotecan metabolism and transport. Values next to the columns indicate the relative contribution of rare genetic variants. c Stacked column plot showing the aggregated frequency of deleterious rare variants involved in irinotecan ADME