Figure 2.

CircHIPK3 expression was down-regulated in osteosarcoma tissues and plasmas, related to poor prognosis. (A) Expression level of four circRNAs in 82 pairs of OS and paracancerous tissues. (B)Expression level of circHIPK3 in plasmas from 50 patients with osteosarcoma before surgery, 10 patients with benign bone tumor and 20 matched healthy individuals. (C) Patients with lower circHIPK3 expression had a shorter overall survival time than those with higher circHIPK3 expression. *P < 0.05, **P < 0.01.