Table 3.

Association between continuous serum bicarbonate and summary cognitive function domains in SPRINT MIND participants

	Model 1, n=2853		Model 2, n=2853		Model 3, n=2804
Domain	Estimate (SEM)	P Value	Estimate (SEM)	P Value	Estimate (SEM)	P Value
Global cognitive function	0.02 (0.005)	<0.01	0.02 (0.006)	<0.01	0.01 (0.006)	0.01
Executive function	0.02 (0.006)	<0.01	0.02 (0.006)	0.004	0.02 (0.006)	0.002
Memory	0.01 (0.006)	0.07	0.008 (0.006)	0.20	0.006 (0.006)	0.35
Attention/concentration	0.01 (0.006)	0.06	0.01 (0.006)	0.04	0.01 (0.006)	0.06
Language	−0.008 (0.006)	0.19	−0.009 (0.006)	0.15	−0.009 (0.006)	0.17

Model 1 adjusted for age, network, education, sex, and race. Model 2 adjusted for model 1 components as well as cardiovascular disease, systolic BP, use of diuretics, and antiacidosis medications (sodium bicarbonate, sodium citrate, citric acid/sodium citrate). Model 3 adjusted for model 2 components as well as eGFR and log-transformed urine albuminuria.