Table 4.

Association of serum bicarbonate with cognitive function domains in the SPRINT MIND MRI subgroup

	Model 1, n=681		Model 2, n=681		Model 3, n=594
Domain	Estimate (SEM)	P Value	Estimate (SEM)	P Value	Estimate (SEM)	P Value
Global cognitive function	0.0391 (0.01)	0.001	0.0358 (0.01)	0.003	0.0328 (0.01)	0.01
Executive function	0.0304 (0.01)	0.02	0.0246 (0.01)	0.06	0.0246 (0.01)	0.07
Memory	0.0255 (0.01)	0.05	0.0256 (0.01)	0.05	0.0203 (0.01)	0.14
Attention/concentration	0.0240 (0.01)	0.07	0.0196 (0.01)	0.15	0.0164 (0.01)	0.26
Language	0.0024 (0.01)	0.86	−0.0005 (0.01)	0.97	0.0078 (0.01)	0.59

Model 1 adjusted for age, network, education, sex, race, cardiovascular disease, systolic BP, use of diuretics and antiacidosis medications (sodium bicarbonate, sodium citrate, citric acid/sodium citrate), eGFR, and log-transformed urine albuminuria. Model 2 adjusted for model 1 components as well as scanner type, intracranial volume, and total abnormal volume. Model 3 adjusted for model 2 components as well as vascular reactivity and cerebral blood flow.