Table 2. Mean percent blood glucose reduction of gliclazide in the presence and absence of aprepitant administration in normal rabbits (n = 6).

Time (hr)	Gliclazide#	Aprepitant∧	Aprepitant + Gliclazide (Single dose treatment)a	Aprepitant + Gliclazide (Multiple dose treatment)b
1	10.45 ± 3.41	02.19 ± 1.12	08.28 ± 2.07	09.67 ± 1.79
2	19.28 ± 6.69	05.40 ± 1.29	24.08 ± 4.76	26.13 ± 6.55
3	36.65 ± 5.61	09.73 ± 2.50	44.62 ± 4.98*	48.87 ± 5.17*
4	23.39 ± 5.12	14.14 ± 3.11	37.89 ± 4.17***	41.18 ± 2.44***
6	17.84 ± 4.52	12.19 ± 2.24	29.47 ± 3.41***	34.37 ± 5.07***
8	12.76 ± 5.80	09.79 ± 2.51	25.12 ± 4.17**	30.75 ± 5.50***
10	10.93 ± 5.39	08.13 ± 3.03	22.74 ± 4.52**	26.93 ± 5.04***
12	07.63 ± 5.66	06.23 ± 2.33	17.31 ± 4.52**	23.52 ± 5.38***
16	05.86 ± 4.91	04.38 ± 2.36	12.06 ± 4.80	19.27 ± 5.64**
20	04.30 ± 4.51	02.67 ± 1.98	08.52 ± 5.21	14.84 ± 7.14*
24	02.83 ± 4.07	01.54 ± 1.83	04.22 ± 5.33	11.53 ± 6.03*

Notes.

Data is represented as mean ±  SD.

^#5.6 mg/1.5 kg b.wt.

^∧8.75 mg/1.5 kg bd wt.

^aSingle dose treatment of aprepitant and single dose treatment of gliclazide.

^bMultiple dose treatment of aprepitant (7 days) and single dose treatment of gliclazide.

^*P < 0.05 compared to gliclazide group.

^**P < 0.01 compared to gliclazide group.

^***P < 0.001 compared to gliclazide group.