Figure 4.

Phase I metabolite production of midazolam, phenacetin, diclofenac, bufuralol, bupropion, and mephenytoin by human‐induced pluripotent stem cells‐derived hepatocytes and human precision‐cut liver slices cultured in static or under flow conditions. The individual values are expressed as pmol·min⁻¹·mg⁻¹ protein. Results are from three independent differentiation experiments and seven donors. PCLS = precision‐cut liver slices; PDMS = polydimethylsiloxane; PS = polystyrene [Colour figure can be viewed at http://wileyonlinelibrary.com]