Figure 5.
Production of 7‐hydroxycoumarin glucuronide (HC‐G; left panel) and 7‐hydrocycoumarine sulfate (HC‐S; right panel) from 7‐hydroxycoumarin by human‐induced pluripotent stem cells‐derived hepatocytes and human precision‐cut liver slices cultured in static or under flow conditions. The individual values are expressed as pmol·hr−1·mg−1 protein. Results are from three independent differentiation experiments and seven donors. PCLS = precision‐cut liver slices; PDMS = polydimethylsiloxane; PS = polystyrene [Colour figure can be viewed at http://wileyonlinelibrary.com]