Table 3.
Association between response groups and cardiovascular events (N = 1600)
| Unadjusted | Adjusteda | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Response group | ΔSBP, mm Hg Mean (SD) | ΔUACR (%) Median (25th to 75th) | Event n (%) | HR | 95% CI | P | HR | 95% CI | P | |
|
Poor responders
(n = 167) |
SBP ≥ 0 mm Hg / UACR ≥ 0% | 12.1 (12.4) | 50.0 (20‐125) | 23 (13.8) | ref | ref | ref | ref | ref | ref |
|
SBP‐only responders
(n = 353) |
SBP < 0 mm Hg / UACR ≥ 0% | −22.7 (14.9) | 46.9 (18‐127) | 21 (6.0) | 0.42 | 0.23–0.76 | 0.004 | 0.48 | 0.26–0.88 | 0.018 |
|
UACR‐only responders
(n = 268) |
SBP ≥ 0 mm Hg / UACR < 0% | 10.0 (10.0) | −47.4 (−74 to −23) | 30 (11.9) | 0.82 | 0.47–1.41 | 0.46 | 0.64 | 0.36–1.13 | 0.121 |
|
Good responders
(n = 812) |
SBP < 0 mm Hg / UACR < 0% | −21.9 (15.4) | −56.7 (−75 to −35) | 54 (6.7) | 0.48 | 0.30–0.78 | 0.003 | 0.51 | 0.30–0.86 | 0.012 |
Abbreviations: HR, hazard ratio; SBP, systolic blood pressure; UACR, urinary albumin creatinine ratio.
a
Adjusted for sex, baseline age, SBP, logUACR, glycated haemoglobin, diastolic blood pressure, estimated glomerular filtration rate, and cardiovascular and peripherovascular morbidity.