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. 2018 Feb 19;143(1):167–178. doi: 10.1002/ijc.31298

Figure 3.

Figure 3

Tumour‐associated TLS development is accompanied with heightened expression of lymphoid chemokines. Temporal qPCR analysis of TLS‐associated genes in the gastric antrum of gp130+/+ mice (WT) and gp130 F/F mice (FFA). Relative gene expression is presented in mice without GC at 4 weeks (a), 3 months (b) and 6 months (c) of age. Expression of the cytokines Il21 (d) and Il27 (e) was also determined in the gastric antrum of 6‐month‐old gp130 F/F and WT mice. In 3‐ and 6‐month‐old gp130 F/F mice, gene expression was also determined in the gastric tumour tissue (FFT) (n = 4 per group at 4 weeks, n = 7 per group at 3 months, n = 6–7 per group at 6 months). Graphs represent mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.