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. 2018 Feb 19;143(1):167–178. doi: 10.1002/ijc.31298

Figure 6.

Figure 6

A TLS gene signature is associated with advanced GC in patients, but has no prognostic significance. (a) Representative immunohistochemistry for CD20+ B cells and CD3+ T cells in serial sections of human GC tissue biopsies showing the presence of TLSs in the tumoural submucosa (Scale bars: 500 µm left images; 125 µm right images). Sequential sections on the right show higher‐power images of a TLS (corresponding to the boxed regions in the left panel) displaying T and B cell segregation. (b–d) Evaluation of the expression of a TLS gene signature comprising CXCL13, CCL19 and CCL21 in TCGA data sets of 176 GC patients with intestinal‐type GC. An association between the TLS gene signature and tumour growth (b), the stage of GC (c) and patient survival (d) is presented. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Scale bars: 500 µm (left); 125 µm (right). [Color figure can be viewed at http://wileyonlinelibrary.com]