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. 2018 Feb 27;39(6):2381–2390. doi: 10.1002/hbm.24008

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© 2018 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The outcome of the mediation analyses. (a) The diagram shows that the relationship between GLx reactivity (GLx/NAA different scores) and memory performance was mediated by functional connectivity between mPFC and hippocampus (high confident remembered vs low confident remembered/incorrect + GLx). GLx different scores were positively associated with mPFC/hippocampus functional connectivity (apath). MPFC/hippocampus functional connectivity predicted memory performance (b‐path). GLx different scores directly predicted memory performance (c‐path) but if controlled for the mediator this effect diminished (c'‐ path). The indirect effect (a, b) was .33 which was statistically significant (Sobel test). (b) The diagram shows that the relationship between GLx reactivity (GLx/NAA different scores) and memory performance seems also mediated by functional connectivity between mPFC and thalamus (high confident remembered vs low confident remembered/incorrect + GLx); however, the indirect effect (a)(b) =.26 was not statistically significant [Color figure can be viewed at http://wileyonlinelibrary.com]