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Design of the intranasal challenge study. A, Subjects were challenged intranasally with either omalizumab, Bet v 1 or placebo on 3 consecutive days (d1‐d3, arrows, top). Blood samples (arrows, bottom) were taken before the first (t1) challenge and on days 21 (t2), 35 (t3) and 56 (t4) (±4 days) after the first challenge. B, Flow chart depicting number of subjects who were screened (n = 24), randomized (n = 15), and who completed (n = 14) the study
