Table 2.
Insulin doses (U/kg) for all dulaglutide 1.5 mg patients and all comparator patients by subgroup and individual study at 6 months
HbA1c | Age | Duration of diabetes | ||||
---|---|---|---|---|---|---|
≤9% | >9% | <65 y | ≥65 y | <10 y | ≥10 y | |
AWARD‐4 | ||||||
Dulaglutide 1.5 mg + insulin lispro | ||||||
Lispro dose | 0.9 ± 0.7 | 1.1 ± 0.6 | 1.0 ± 0.6 | 1.0 ± 0.9 | 1.0 ± 0.6 | 1.0 ± 0.7 |
Insulin glargine + insulin lispro | ||||||
Total daily insulin dose | 1.3 ± 0.7 | 1.6 ± 0.8 | 1.4 ± 0.8 | 1.4 ± 0.7 | 1.5 ± 0.9 | 1.3 ± 0.7 |
Glargine dose | 0.7 ± 0.4 | 0.8 ± 0.4 | 0.7 ± 0.4 | 0.7 ± 0.3 | 0.7 ± 0.5 | 0.7 ± 0.3 |
Lispro dose | 0.7 ± 0.4 | 0.8 ± 0.5 | 0.7 ± 0.4 | 0.7 ± 0.4 | 0.8 ± 0.5 | 0.7 ± 0.4 |
AWARD‐9 | ||||||
Dulaglutide 1.5 mg + insulin glargine | ||||||
Glargine dose | 0.6 ± 0.3 | 0.7 ± 0.3 | 0.6 ± 0.3 | 0.5 ± 0.3 | 0.6 ± 0.3 | 0.6 ± 0.3 |
Placebo + insulin glargine | ||||||
Glargine dose | 0.6 ± 0.3 | 0.9 ± 0.5 | 0.7 ± 0.4 | 0.6 ± 0.3 | 0.7 ± 0.4 | 0.7 ± 0.3 |
Abbreviation: HbA1c, glycated haemoglobin.
Data are presented as mean ± SD. Insulin lispro was administered three times daily.