Figure 2.
Correlation strengths of gastric cancer (GC)-enriched and GC-depleted bacteria increased with disease progression. Correlation networks of GC-enriched and GC-depleted operational taxonomic units (OTUs) in: superficial gastritis, atrophic gastritis, intestinal metaplasia and GC. SparCC algorithm was used to estimate correlation coefficients and adjust for compositional effects. Cytoscape V.3.4.0 was used for network construction. A subset of significant correlations with strengths of at least 0.2 were selected for visualisation. The size and colour of the nodes correspond to weighted node connectivity (WNC) scores). Peptostreptococcus_OTU16 (3), Parvinomonas_OTU35 (6) and Streptococcus_OTU68 (8), Dialister_OTU151 (13), Slackia_OTU174 (14) have significant WNC scores (p<0.05).