Table 3.

Significant associations between DNA methylation and gene expression (n=2802)

CpG	Annotated gene	Ensembl_ID	Gene	B	SE	P adjusted
Women
cg16884400	ATP5G3	ENSG00000154518	ATP5G3	0.098	0.005	2.94×10−2
Never-smokers
cg03181524	RYR1	ENSG00000196218	RYR1	−0.881	0.157	6.74×10−7
		ENSG00000182472	CAPN12	−0.877	0.194	1.86×10−4
		ENSG00000267892	CTD-2540F13.2	−0.916	0.234	2.76×10−3
Subjects with airway obstruction
cg10059942	HMX2	ENSG00000154473	BUB3	1.062	0.378	3.45×10−2
		ENSG00000138161	CUZD1	1.474	0.536	4.18×10−2
cg20869844	RAB19	ENSG00000146955	RAB19	−3.479	1.134	2.37×10−2
		ENSG00000157764	BRAF	−0.724	0.248	3.90×10−2
cg11465769	MYT1L	ENSG00000130508	PXDN	4.973	1.445	2.32×10−3
cg19084031*	RP11-1008C21.2	ENSG00000259225	RP11-1008C21.1	−1.711	0.177	2.34×10−21
		ENSG00000166068	SPRED1	−0.513	0.086	1.18×10−8
cg04035638	PSORS1C3;POU5F1	ENSG00000225851	HLA-S	10.888	1.621	7.57×10−10
		ENSG00000204580	DDR1	1.678	0.328	1.25×10−5
		ENSG00000137310	TCF19	1.239	0.345	1.33×10−2
		ENSG00000228789	HCG22	−5.066	1.421	1.48×10−2
		ENSG00000234745	HLA-B	−1.337	0.389	2.46×10−2

No data in BIOS-BBMRI were available for cg08855288, cg15793258 and cg27484412. In online supplemental table 5, the results of all CpGs and genes with expression data available within 1 Mb are shown.

*CpG also identified in pesticide exposure×airway obstruction analysis.

B, beta; CpG, DNA methylation site; P adjusted, Bonferroni-corrected P values based on all probesets located within the 1 Mb window.