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. 2018 Feb 26;131(21):2357–2366. doi: 10.1182/blood-2017-12-820910

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Figure 1. — Complete response on ibrutinib. (A) Cumulative best response in 81 evaluable patients. (B) Forest plot showing CR rates at best response in subgroups divided by clinical and laboratory criteria; the dashed line marks the CR rate in all patients (23.5%). Whiskers indicate 95% CI. *Trend in CR rate difference between low and advanced Rai stages (P = .054). **Spleen size was not evaluated in 2 patients with history of splenectomy. (C) Status of CR criteria in 79 patients; spleen (volume assessed by CT), target lymph nodes (LN), absolute lymphocyte count (ALC), bone marrow infiltration and cellularity (Marrow), and hematologic recovery (Heme). Twenty-three (28%) patients met all CR criteria (blue blocks); red blocks mark CR criteria not met. B2M, β2-microglobulin; IGHV-M, IGHV mutated; IGHV-U, IGHV unmutated.