Tell me about the idea (main theme) of your research project. (4–5 lines) Can you give a little background about why this project is interesting in general? What were some especially memorable moments during this research experience? What were some of the challenges, and (how) did they get resolved? What are some likely next steps for continuing the project, and how do you envision this happening? Extrapolate out three years—where could this project go?

Description of student responses regarding their overall learning experience Theme 1. Engaging in broadly relevant and important work CRISPR-Cas9 technology for genome engineering “The CRISPR Cas9 system is so new, quick, specific and easy to do.” “Our project was interesting because of the new technology. The technology opens up a new realm of possibilities since it is so simple … and clean (as compared to the other technologies that knock out genes).” “It is interesting because there are real effects of our research which could help with osteoarthritis. So it’s interesting because of the benefits.” Use of model systems to understand human gene function “This gene is also present in humans so it’s interesting because we can connect something with zebrafish. We can see its function in like something smaller and relate it to something much bigger. Possibly figure out a cure or some kind of treatment from this information.” “I think probably one of the most memorable experience for both of us was seeing the zebrafish injections because it all culminated to that.” “I also really enjoyed going to the zebrafish facility. I think it was really cool to see the developing embryos and all the crazy stacks of fish.” Theme 2. Influence on career path (PhD; MD vs. MD-PhD) “This class made me more aware about research than I was before to where I might consider doing research in the future (as a MD-PhD) as compared to just MD.” “I don’t want to be a PI who sits around and writes grants but it would be cool to see patients and to be at the front line of research in your field.” Theme 3. Communicating science (poster presentation) “The poster presentation was pretty cool because we created our own research project. It’s cool to culminate all of our work into one thing and look at all what we have done and presented to people. And having other people be really interested.” “Our poster presentation was definitely a big one (a memorable moment). Presenting to eight judges—I have never done that before.”