Table 2.
Associations of plasma metabolites with change in eGFR in the Nutrition and Health of Aging Population in China study
| Metabolite | Change in eGFR (ml/min per 1.73 m2 per year) | Incident Reduced eGFR | ||
|---|---|---|---|---|
| β (95% Confidence Interval) | P Value | Relative Risk (95% Confidence Interval) | P Value | |
| Cysteine | −0.25 (−0.33 to −0.17) | 2.7E−09 | 1.25 (1.13 to 1.39) | 3.5E−05a |
| C3DC | −0.19 (−0.27 to −0.11) | 5.8E−06 | 1.18 (1.06 to 1.32) | 2.6E−03a |
| C10 | −0.17 (−0.25 to −0.10) | 1.6E−05 | 1.20 (1.07 to 1.33) | 1.1E−03a |
| C20 | −0.18 (−0.26 to −0.09) | 3.8E−05 | 1.12 (1.01 to 1.24) | 3.3E−02 |
| C14:1OH | −0.17 (−0.25 to −0.09) | 4.5E−05 | 1.17 (1.06 to 1.29) | 1.9E−03a |
| C18 | −0.17 (−0.26 to −0.09) | 5.6E−05 | 1.17 (1.06 to 1.30) | 2.0E−03a |
| C18:2 | −0.17 (−0.25 to −0.09) | 1.0E−04 | 1.18 (1.07 to 1.30) | 6.0E−04a |
| C16:2 | −0.16 (−0.24 to −0.07) | 2.0E−04 | 1.16 (1.05 to 1.28) | 4.1E−03 |
| Phenylalanine | −0.16 (−0.24 to −0.07) | 2.0E−04 | 1.16 (1.05 to 1.29) | 4.0E−03 |
| Glutamine | −0.15 (−0.23 to −0.07) | 3.0E−04 | 1.14 (1.02 to 1.27) | 1.6E−02 |
| C8 | −0.14 (−0.22 to −0.06) | 4.0E−04 | 1.15 (1.03 to 1.27) | 1.1E−02 |
| C20:4 | −0.15 (−0.23 to −0.07) | 4.0E−04 | 1.19 (1.08 to 1.31) | 4.0E−04a |
| C5OH | −0.15 (−0.23 to −0.06) | 4.0E−04 | 1.10 (1.01 to 1.21) | 3.7E−02 |
Data are annual change in eGFR or relative risk per SD increase in metabolite concentration, after adjustment for age, sex, region (Beijing/Shanghai), residence (urban/rural), education, current smoking, current drinking, physical activity, body mass index, lipid-lowering medication use, HDL, LDL, cardiovascular disease, hypertension, type 2 diabetes, and eGFR at baseline. Only metabolites associated with annual eGFR change after Bonferroni correction for multiple testing of the 56 metabolites (P<8.9E−04) are shown.
Significant association with incident reduced eGFR with P<3.8E−03 after Bonferroni correction for multiple testing of the 13 metabolites associated with annual eGFR change.