Table 3.
Associations of BP parameters with composite cardiovascular outcomes in the Chronic Renal Insufficiency Cohort Study in multiple regression models
| Variable and Level, mm Hg | Model A | Model B | ||||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | Overall P Value | Harrell c (95% CI) | HR (95% CI) | P Value | Overall P Value | Harrell c (95% CI) | |
| Brachial systolic BP, mm Hg | ||||||||
| <112 | <0.001 | 0.61 (0.58 to 0.63) | <0.001 | 0.76 (0.73 to 0.79) | ||||
| 112 to <124 | 1.03 (0.78 to 1.36) | 0.84 | 0.99 (0.72 to 1.38) | 0.97 | ||||
| 124 to <138 | 1.40 (1.07 to 1.83) | 0.01 | 0.95 (0.68 to 1.32) | 0.76 | ||||
| ≥138 | 2.55 (2.00 to 3.24) | <0.001 | 1.59 (1.17 to 2.17) | 0.003 | ||||
| Central systolic BP, mm Hg | ||||||||
| <102 | <0.001 | 0.59 (0.57 to 0.62) | 0.002 | 0.76 (0.73 to 0.79) | ||||
| 102 to <113 | 1.13 (0.86 to 1.48) | 0.38 | 1.26 (0.91 to 1.75) | 0.16 | ||||
| 113 to <127 | 1.31 (1.01 to 1.71) | 0.04 | 1.12 (0.81 to 1.55) | 0.48 | ||||
| ≥127 | 2.30 (1.81 to 2.92) | <0.001 | 1.69 (1.24 to 2.31) | <0.001 | ||||
| Brachial pulse pressure, mm Hg | ||||||||
| <42 | <0.001 | 0.65 (0.62 to 0.67) | <0.001 | 0.76 (0.73 to 0.79) | ||||
| 42 to <54 | 1.63 (1.17 to 2.27) | 0.004 | 1.24 (0.83 to 1.85) | 0.29 | ||||
| 54 to <68 | 2.60 (1.90 to 3.56) | <0.001 | 1.57 (1.07 to 2.32) | 0.02 | ||||
| ≥68 | 4.49 (3.33 to 6.05) | <0.001 | 2.07 (1.40 to 3.05) | <0.001 | ||||
| Central pulse pressure, mm Hg | ||||||||
| <32 | <0.001 | 0.64 (0.62 to 0.66) | <0.001 | 0.76 (0.73 to 0.79) | ||||
| 32 to <42 | 1.84 (1.36 to 2.50) | <0.001 | 1.39 (0.96 to 2.02) | 0.08 | ||||
| 42 to<55 | 2.55 (1.90 to 3.42) | <0.001 | 1.54 (1.06 to 2.23) | 0.02 | ||||
| ≥55 | 4.18 (3.16 to 5.53) | <0.001 | 2.11 (1.46 to 3.05) | <0.001 | ||||
| Augmentation index, % | ||||||||
| <20 | 0.20 | 0.52 (0.50 to 0.55) | 0.50 | 0.76 (0.73 to 0.79) | ||||
| 20 to <28 | 0.98 (0.76 to 1.26) | 0.87 | 0.87 (0.64 to 1.16) | 0.34 | ||||
| 28 to <35 | 1.09 (0.86 to 1.39) | 0.48 | 0.92 (0.68 to 1.23) | 0.56 | ||||
| ≥35 | 1.23 (0.97 to 1.57) | 0.08 | 1.06 (0.78 to 1.44) | 0.70 | ||||
| Aortic time to return, ms | ||||||||
| <129 | 0.002 | 0.54 (0.52 to 0.57) | 0.31 | 0.76 (0.73 to 0.79) | ||||
| 129 to <137 | 0.90 (0.72 to 1.14) | 0.39 | 0.82 (0.62 to 1.07) | 0.15 | ||||
| 137 to <145 | 0.87 (0.69 to 1.10) | 0.24 | 0.89 (0.67 to 1.18) | 0.42 | ||||
| ≥145 | 0.62 (0.49 to 0.80) | <0.001 | 0.76 (0.56 to 1.04) | 0.09 | ||||
| Buckberg index | ||||||||
| <126 | <0.001 | 0.60 (0.57 to 0.62) | 0.22 | 0.756 (0.73 to 0.79) | ||||
| 126 to <148 | 0.69 (0.56 to 0.85) | <0.001 | 0.86 (0.66 to 1.11) | 0.24 | ||||
| 148 to <174 | 0.46 (0.36 to 0.58) | <0.001 | 0.72 (0.53 to 0.98) | 0.04 | ||||
| ≥174 | 0.42 (0.33 to 0.53) | <0.001 | 0.85 (0.62 to 1.17) | 0.32 | ||||
Model A is the unadjusted model. Model B is adjusted for age, sex, race/ethnicity, Chronic Renal Insufficiency Cohort clinical center, smoking status, weight, body mass index, diabetes status, statin use, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use, hemoglobin, 24-hour urine proteinuria, and eGFR. HR, hazard ratio; 95% CI, 95% confidence interval.