Table 2.
Enrollment laboratory values
| Variable | ATN Study | VALID Study | ||||||
|---|---|---|---|---|---|---|---|---|
| All (n=817) | Alive (n=402) | Dead (n=415) | P Valuea | All (n=710) | Alive (n=449) | Dead (n=261) | P Valuea | |
| Routine labs, median (IQR) | ||||||||
| White cell count, per mm3 | 13 (9–19) | 13 (9–18) | 14 (8–20) | 0.46 | 14 (9–19) | 13 (9–19) | 14 (9–19) | 0.51 |
| Hemoglobin, g/dl | 9.8 (8.9–10.8) | 9.7 (8.8–10.6) | 9.9 (9.0–10.9) | 0.04 | 9.8 (8.8–11.0) | 10.0 (8.9–11.1) | 9.7 (8.8–11.0) | 0.50 |
| Creatinine, mg/dl | 3.9 (2.9–5.1) | 4.3 (3.2–5.6) | 3.6 (2.7–4.6) | <0.001 | 1.1 (0.9–1.7) | 1.0 (0.8–1.4) | 1.4 (1.0–2.1) | <0.001 |
| Albumin, g/dl | 2.3 (1.9–2.8) | 2.4 (1.9–3.0) | 2.3 (1.8–2.8) | 0.03 | ||||
| cFGF23, RU/ml | ||||||||
| Median | 3608 | 1918 | 5819 | <0.001 | 603 | 483 | 1183 | <0.001 |
| IQR | 1079–12,983 | 740–7736 | 1656–18,731 | 212–1882 | 181–1218 | 366–4344 | ||
| iFGF23, pg/ml | ||||||||
| Median | 88 | 81 | 97 | 0.36 | 44 | 38 | 51 | <0.001 |
| IQR | 30–239 | 24–266 | 40–224 | 24–87 | 23–76 | 27–107 | ||
| Other markers, median (IQR)b | ||||||||
| Calcium, mg/dl | 7.7 (7.1–8.3) | 7.8 (7.2–8.4) | 7.7 (7.0–8.3) | 0.33 | 7.8 (7.4–8.3) | 7.8 (7.5–8.3) | 7.8 (7.4–8.3) | 0.52 |
| Phosphate, mg/dl | 5.2 (4.0–6.7) | 5.1 (4.0–6.7) | 5.2 (4.0–6.7) | 0.79 | 3.3 (2.5–4.3) | 3.2 (2.5–4.2) | 3.4 (2.4–4.7) | 0.44 |
| Parathyroid hormone, pg/ml | 304 (118–588) | 306 (118–567) | 301 (120–592) | 0.77 | ||||
| 25-hydroxyvitamin D, ng/ml | 10 (6–14) | 11 (7–14) | 9 (6–13) | 0.01 | ||||
| 1,25-dihydroxyvitamin D, pg/ml | 12 (8–18) | 11 (7–20) | 12 (8–18) | 0.73 | ||||
| 24,25-dihydroxyvitamin D3, ng/ml | 0.4 (0.3–0.7) | 0.5(0.3–0.7) | 0.4 (0.3–0.7) | 0.82 | ||||
| IL-6, pg/ml | 166 (74–539) | 125 (57–281) | 230 (104–911) | <0.001 | ||||
ATN, ARF Trial Network; VALID, Validating Acute Lung Injury biomarkers for Diagnosis; IQR, interquartile range; cFG;23, c-terminal fibroblast growth factor 23; RU/ml, reference units per millilter; iFGF23, intact fibroblast growth factor 23.
a
Comparison between patients alive versus dead at day 60.
b
Parathyroid hormone and vitamin D metabolite levels were available in a subcohort (n=400) of patients in the ATN study and were not available in VALID. IL-6 levels were available in all participants in the ATN study and were not available in VALID.