Qualitative and quantitative data were synthesized to develop a final list of top-prioritized physical and mood symptoms. Focus group and survey participants identified a range of physical and mood symptoms, often recognizing a connection between physical and mood symptoms. After considering symptom duration, frequency, unpredictability, and social and financial effects, the participants prioritized the physical symptoms of insomnia, fatigue, and cramps and mood symptoms of anxiety, depression, and frustration as the most important symptoms to address when developing new or improved symptom management therapies.