Fig. 8. (A) Amide temperature coefficients of the least and most stable Pin 1 analogs 8 and 11, respectively, obtained by analysing a series of TOCSY spectra acquired from 288 K to 308 K. The asterisks indicate the residues that show a change greater than or equal to 1 ppb K^–1. The red dotted line marks the barrier at –4.6 ppb K^–1, above which the values indicate the absence of intramolecular hydrogen bonding. (B) Residues showing a change greater than or equal to 1 ppb K^–1 are highlighted in pink, which are mapped on Pin 1-NG (PDB ID: ; 1ZCN).