Table 1.
Cell types involved in TNT-mediated mitochondria transfer with MSC and biological outcome.
| References | Cell types involved in TNTs with MSCs | Cargo transferred | Biological Outcome |
|---|---|---|---|
| Spees et al. (2006) | A549 ρ0 lung epithelial cells | Mitochondria/mtDNA | Aerobic respiration restoration |
| Plotnikov et al. (2008) | Rat cardiomyocytes | Mitochondria | Restoration of cardiomyocytes bioenergetics |
| Plotnikov et al. (2010) | Rat renal tubular cells | Mitochondria | MSC differentiation into kidney tubular cells |
| Acquistapace et al. (2011) | Adult cardiomyocytes | Mitochondria | Conversion to progenitor-like state by metabolic reprogramming |
| Islam et al. (2012) | Damaged murine alveolar epithelial cells | Mitochondria | Tissue repair (ATP level restoration, pulmonary surfactant secretion) |
| Vallabhaneni et al. (2012) | Vascular smooth muscle cells | Mitochondria | Increase in MSC proliferation |
| Pasquier et al. (2013) | Human ovarian and breast cancer cell lines | Mitochondria | Increased doxorubicin chemoresistance |
| Ahmad et al. (2014) | Stressed murine lung epithelial cells | Mitochondria | Lung injury repair and mouse survival |
| Li et al. (2014) | Lung epithelial cells exposed with cigarette smoke | Mitochondria | Decrease in cigarette-smoke-induced alveolar damage |
| Liu et al. (2014) | Human umbilical vein endothelial cells (HUVEC) | Mitochondria | Injury rescue, increased oxygen consumption |
| Caicedo et al. (2015) | MDA-MB-231 breast cancer cells | Mitochondria | Increased OXPHOS, ATP production, invasion & proliferation |
| Han et al. (2015) | Ischemic H9c2 rat cardiomyocytes | Mitochondria | Apoptosis decrease, mitochondrial function restoration |
| Tan et al. (2015) | Murine B16 ρ0 melanoma and 4T1 ρ0 breast carcinoma | mtDNA | Restored respiratory functions, increased tumor-initiation |
| Jackson et al. (2016) | Macrophages | Mitochondria | Enhanced macrophage phagocytosis and improved bioenergetics |
| Jiang et al. (2016) | Corneal epithelial cells | Mitochondria | Protection against oxidative-stress-induced mitochondrial damage |
| Moschoi et al. (2016) | Acute Myeloid Leukemia cells | Mitochondria | Increased chemoresistance to ARA-C |
| Zhang et al. (2016) | Cardiomyocytes | Mitochondria | Rescue of anthracycline-induced myopathy |
| Nzigou Mombo et al. (2017) | Glioblastoma stem cells | Mitochondria | |
| Sanchez et al. (2017) | Wharton's jelly mesenchymal stem cells | Mitochondria |