Figure 1.

CB002 activates luciferase-based p53-reporter activity in 3 different human colorectal cancer cell lines in a dose-dependent manner. A. Representative images of luciferase-based p53-reporter activity assays are shown at 3 hrs. B-D. Quantification of the luciferase-based p53-reporter activity assays in 3 different cell lines incubated from 3–24 hrs with CB002. E. Representative images of the p53-reporter activity assays are shown at 2 hrs for HCT116 p53-null cells. Three replicates were done for each concentration of CB002 as indicated in the figure panels.