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CB002 proposed mechanism of action. CB002 induces the expression of NOXA and the degradation of mutant p53 through the ubiquitin proteasome system. NOXA and atg5 expression are required for apoptotic cell death. The relationship between ATG5 and NOXA, if any, remains to be determined. Furthermore, CB002 induces autophagy which aids apoptotic cell death in drug-treated cells.
