Figure 1.

Timeline of key discoveries pertaining to CIC research. Cic was discovered in 2000 in Drosophila, and two years later it was identified in mammals. Its implication in cancer was originally reported in 2006 as a component of oncogenic fusions, but inactivating point mutations were not found until 2011. The last year has been particularly prolific in new findings about CIC function in mammalian development and cancer, including its roles in metastasis formation and therapy resistance. References are indicated in each box.