Table 1. Pathogen selection across worldwide populations.
| # | Disease | Taxonomy ID | P-Value | Q-Value | Genes | Effect Size |
|---|---|---|---|---|---|---|
| 1 | Yersinia pestis | 632 | 2.08x10-8 | 5.62x10-7 | 730 | 0.714 |
| 2 | HIV-1 | 11676 | 3.70x10-6 | 4.78x10-5 | 373 | 0.712 |
| 3 | Zaire Ebola virus | 186538 | 5.31x10-6 | 4.78x10-5 | 6 | 0.869 |
| 4 | Francisella tularensis | 263 | 3.13x10-5 | 1.87x10-4 | 261 | 0.718 |
| 5 | Dengue virus | 12637 | 3.47x10-5 | 1.87x10-4 | 20 | 0.766 |
| 6 | Human resp. syncytial virus | 11250 | 3.61x10-4 | 1.62x10-3 | 46 | 0.742 |
| 7 | Measles virus | 11234 | 1.20x10-3 | 4.64x10-3 | 85 | 0.726 |
| 8 | Rubella virus | 11041 | 2.96x10-3 | 1.00x10-2 | 28 | 0.732 |
| 9 | Bacillus anthracis | 1392 | 1.04x10-4 | 3.23x10-2 | 493 | 0.700 |
| 10 | Human herpesvirus 4 | 10376 | 2.87x10-2 | 7.76 x10-2 | 50 | 0.712 |
| 11 | Human herpesvirus 8 | 37296 | 4.02x10-2 | 9.86x10-2 | 44 | 0.707 |
| 12 | Human herpesvirus 1 | 10298 | 5.06x10-2 | 9.90x10-2 | 22 | 0.731 |
| 13 | Human herpesvirus 5 | 10359 | 5.19x10-2 | 9.90x10-2 | 5 | 0.787 |
| 14 | Sandfly fever Sicilian virus | 28292 | 5.28x10-2 | 9.92x10-2 | 11 | 0.739 |
| 15 | Vaccinia virus | 10245 | 5.50x10-2 | 9.99x10-2 | 27 | 0.702 |
| 16 | Hepatitis C virus | 11103 | 6.65x10-2 | 0.101 | 243 | 0.702 |
| 17 | Staphylococcus aureus | 1280 | 8.32x10-2 | 0.121 | 7 | 0.712 |
| 18 | Escherichia coli | 562 | 0.120 | 0.168 | 28 | 0.695 |
| 19 | California encephalitis virus | 35305 | 0.134 | 0.179 | 13 | 0.716 |
| 20 | Human mastadenovirus C | 129951 | 0.637 | 0.777 | 9 | 0.693 |
| 21 | West Nile virus | 11082 | 0.655 | 0.779 | 10 | 0.674 |
| 22 | Human adenovirus C | 129951 | 0.637 | 0.789 | 9 | 0.703 |
| 23 | Alphapapilloma virus 9 | 337041 | 0.762 | 0.866 | 6 | 0.655 |
| 24 | Simian virus 40 | 10633 | 0.785 | 0.886 | 5 | 0.700 |
| 25 | Influenza A virus | 11320 | 0.886 | 0.945 | 107 | 0.692 |
| 26 | Hepatitis B virus | 10407 | 0.998 | 0.998 | 9 | 0.641 |
Human genes interacting with 26 pathogens were probed for signs of positive selection across 53 worldwide populations in the Human Genome Diversity Panel. A lower q-value indicates selection for the respective pathogen. The effect size of each disease is the mean of effect size across all populations.