Table 2. Overrepresentation of HIV human interactome genes in GWASes.
| P < 1e-5 | P < 1e-10 | |||
|---|---|---|---|---|
| # of shared SNPs | Fold enrichment | # of shared SNPs | Fold enrichment | |
| iHS > 0 | 3 | 3.03 | 2 | 3.84 |
| iHS > 2 | 3 | 3.37 | 2 | 4.27 |
| iHS > 3 | 2 | 4.33 | 2 | 8.22* |
| iHS > 4 | 2 | 19.57** | 2 | 37.17** |
SNPs in human genes in the HIV interactome and under natural selection are enriched in GWAS of HIV susceptibility/progression. P value thresholds for HIV GWAS and for iHS thresholds are indicated. Fisher’s exact test was used to calculate the significance of the enrichment.
* = p < 0.05.
** = p< 0.01