Table 2. Histopathological findings in the 46 patients and subsequent outcome.
| Histopathological findings | Patientsa | ICU mortalitya | |
|---|---|---|---|
| Pulmonary fibrosis | 18 | 13 | |
| UIP | 7 | 5 | |
| Drug-induced | 4 | 2 | |
| Systemic disease | 2 | 1 | |
| Post radiotherapy | 2 | 2 | |
| NSIP | 3 | 3 | |
| Organizing pneumonia | 11 | 6 | |
| DAD onlyb | 5 | 2 | |
| Infectious pneumoniac,d | 4 | 3 | |
| Neoplasia | 2 | 1 | |
| Desquamative interstitial pneumoniae | 1 | 1 | |
| Respiratory bronchiolitis | 1 | 0 | |
| Pulmonary alveolar proteinosis | 1 | 0 | |
| Pulmonary infarction | 1 | 1 | |
| Normal | 1 | 0 |
a, Number of patients.
b, DAD was also observed in 16 other patients but combined with other lesions: pulmonary fibrosis (N = 9), organizing pneumonia (N = 3), infectious pneumonia (N = 3), intra-alveolar hemorrhage (N = 1).
c, EBV, CMV, nocardia, adenovirus.
d, no ventilator-associated pneumonia.
e, 68 years old patient with tobacco use having OLB for severe hypoxemia.
DIP was diagnosed, the patient died 49 days post OLB due to persistent hypoxemia. DAD, diffuse alveolar damage; DIP, desquamative interstitial pneumonia; ICU, intensive care unit; NSIP, Non-specific interstitial pneumonia; UIP, usual interstitial pneumonia.