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. Author manuscript; available in PMC: 2018 May 25.
Published in final edited form as: Sci Transl Med. 2017 Nov 29;9(418):eaao6298. doi: 10.1126/scitranslmed.aao6298

Fig. 1. Limb RIPC caused an increase in circulating irisin and translocation of irisin to injured lung alveoli.

Fig. 1

(A) Western blot of serum samples derived from mice subjected to remote ischemic preconditioning (RIPC) (20 μl of serum per lane). Colloidal staining served as loading control. Time course of RIPC-induced elevation of irisin in serum (*P < 0.05 versus control; n = 4). (B) Effect of ischemia/reperfusion (IR) on irisin concentration in mouse serum (*P < 0.05 versus sham and #P < 0.05 versus IR group; n = 6). (C) Time-dependent changes in irisin concentration in serum from mice after RIPC, with or without IR injury, determined by liquid chromatography–mass spectrometry (LC-MS) (*P < 0.05 versus non-IR sham mice and #P < 0.05 versus IR mice 0 min after RIPC; n = 6). (D) Immunohistochemical staining showed irisin expression in the IR-injured lung tissue from mice subjected to RIPC and lung IR injury (*P < 0.05 versus non-IR sham group and #P < 0.05 versus IR only group; n = 5; scale bars, 50 μm). OD, optical density.