Table 1. Appearance of disease after bronchoscopic instillation of Mtb into rabbits.
Numbers in parentheses represent time (in weeks) after infection. The terms small, some, large, and huge represent the diameter of disease lesions, ≤0.5, 0.5 to 1.0, 1.0 to 2, and ≥2 cm, respectively. Mycobacterium tuberculosis, Mtb; CFU, colony-forming factor; CT, computed tomography.
| Concentration of Mtb H37Rv strain (CFU/ml) | Volume (in milliliters) per instillation per rabbit | First CT scan result (weeks after infection) | Second CT scan or clinical result (weeks after infection) |
|---|---|---|---|
| 5 × 104 | 1.2 | No sign of disease (3) | No disease (8) |
| 1.2 | Small consolidation (3) | Clear (8) | |
| 1.2 | Small consolidation (3) | Clear (8) | |
| 5 × 105 | 0.2 | Some consolidation (3) | Clear (6) |
| 0.4 | Some consolidation (3) | Clear (6) | |
| 0.6 | Some consolidation (3) | Clear (6) | |
| 1.2 | Some consolidation (3) | Clear (8) | |
| 1.2 | Some consolidation (3) | Two cavities (6) | |
| 1.2 | Some consolidation (3) | Two cities (7) | |
| 5 × 106 | 0.2 | Some consolidation (3) | Two cavities (6) |
| 0.4 | Large consolidation (3) | Some diffusion (8) | |
| 0.6 | Large consolidation (3) | One cavity (3) | |
| 1.2 | Huge consolidation (3) | Sacrificed (3) | |
| 1.2 | Huge consolidation (3) | Sacrificed (3) | |
| 1.2 | Huge consolidation (3) | Sacrificed (3) | |
| 5 × 107 | 0.15 | Large consolidation (1) | Three cavities (4) |
| 0.30 | Large consolidation (1) | One cavity (4) | |
| 5 × 108 | 0.15 | Large consolidation (1) | Two cavities (4) |