Table 3.
Genes differentially expressed between degenerative and traumatic tears
| Gene symbol | Gene name | Class | Degenerative tear (mean±S.E.M.) | Traumatic tear (mean±S.E.M.) | Fold change | Description | P value |
|---|---|---|---|---|---|---|---|
| IL1A | Interleukin 1 alpha | Cytokine | 0.021±0.011 | 0.22±0.016 | 10.48 | Down in degenerative tears | 0.965 |
| IL1B | Interleukin 1 beta | Cytokine | 0.004±0.001 | 0.019±0.012 | 4.75 | Down in degenerative tears | 0.361 |
| IL6 | Interleukin 6 | Cytokine | 0.016±0.007 | 0.023±0.020 | 1.44 | Down in degenerative tears | 0.677 |
| TNF | Tumor necrosis factor alpha | Cytokine | 0.003±0.001 | 0.004±0.003 | 1.33 | Down in degenerative tears | 0.700 |
| ADAMTS4 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | Metalloproteinase | 0.022±0.010 | 0.017±0.010 | 1.26 | Up in degenerative tears | 0.924 |
| ADAMTS5 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | Metalloproteinase | 0.025±0.012 | 0.017±0.010 | 1.48 | Up in degenerative tears | 0.886 |
| BMP2 | Bone morphogenetic protein 2 | Receptor ligand | 0.006±0.002 | 0.025±0.023 | 4.17 | Down in degenerative tears | 0.538 |
| MMP1 | Matrix metalloproteinase 1 | Metalloproteinase | 0.018±0.010 | 0.056±0.034 | 3.11 | Down in degenerative tears | 0.011 |
| MMP3 | Matrix metalloproteinase 3 | Metalloproteinase | 0.045±0.017 | 0.110±0.070 | 2.44 | Down in degenerative tears | 0.016 |
| MMP9 | Matrix metalloproteinase 9 | Metalloproteinase | 0.010±0.005 | 0.021±0.017 | 2.10 | Down in degenerative tears | 0.838 |
| MMP13 | Matrix metalloproteinase 13 | Metalloproteinase | 0.023±0.010 | 0.013±0.006 | 1.79 | Up in degenerative tears | 0.914 |
| IL8 | Interleukin 8 | Chemokine | 0.010±0.003 | 0.061±0.040 | 6.10 | Down in degenerative tears | <0.001 |
| CCL3 | Chemokine (C-C motif) ligand 3 | Chemokine | 0.005±0.002 | 0.028±0.021 | 5.60 | Down in degenerative tears | 0.384 |
| CCL3L1 | Chemokine (C-C motif) ligand 3-like 1 | Chemokine | 0.002±0.001 | 0.016±0.011 | 8.00 | Down in degenerative tears | 0.282 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1 | Chemokine | 0.003±0.001 | 0.003±0.001 | 1.03 | Up in degenerative tears | 0.750 |
| CXCL3 | Chemokine (C-X-C motif) ligand 3 | Chemokine | 0.003±0.001 | 0.016±0.011 | 5.33 | Down in degenerative tears | 0.322 |
| CXCL6 | Chemokine (C-X-C motif) ligand 6 | Chemokine | 0.008±0.003 | 0.062±0.044 | 7.75 | Down in degenerative tears | <0.001 |
| CCL20 | Chemokine (C-C motif) ligand 20 | Chemokine | 0.005±0.002 | 0.017±0.011 | 3.40 | Down in degenerative tears | 0.228 |
| COL1A1 | Collagen type 1, A1 | Extracellular matrix | 0.585±0.205 | 0.098±0.038 | 5.98 | Up in degenerative tears | 0.058 |
| COL2A1 | Collagen type 2, A1 | Extracellular matrix | 0.024±0.009 | 0.026±0.009 | 1.08 | Down in degenerative tears | 0.504 |
| ACAN | Aggrecan | Extracellular matrix | 0.042±0.012 | 0.009±0.006 | 4.39 | Up in degenerative tears | 0.351 |
| NFkB1A | Nuclear factor kappa B1 A | Transcription factor | 0.019±0.007 | 0.023±0.017 | 1.21 | Down in degenerative tears | 0.622 |
| NFkB2 | Nuclear factor kappa B2 | Transcription factor | 0.012±0.008 | 0.016±0.011 | 1.33 | Down in degenerative tears | 0.510 |
| IkBA | Inhibitory kappa B A | Transcription factor | 0.012±0.003 | 0.021±0.012 | 1.75 | Down in degenerative tears | 0.189 |
| ADIPOQ | Adiponectin | Adipokine | 0.012±0.007 | 0.007±0.005 | 1.73 | Up in degenerative tears | 0.755 |
| APLN | Apelin | Adipokine | 0.293±0.269 | 0.158±0.100 | 1.85 | Up in degenerative tears | 0.821 |
| LEP | Leptin | Adipokine | 0.005±0.003 | 0.002±0.001 | 3.18 | Up in degenerative tears | 0.224 |
| RETN | Resistin | Adipokine | 0.014±0.009 | 0.005±0.003 | 2.91 | Up in degenerative tears | 0.210 |
P values in boldface are statistically significant at 5% level. S.E.M. = standard error of the mean