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. Author manuscript; available in PMC: 2019 Jan 25.
Published in final edited form as: Cell. 2018 Jan 25;172(3):590–604.e13. doi: 10.1016/j.cell.2017.12.032

Figure 7. SG Form from Pre-existing PPIs Are Especially Diverse in Neuronal Cells and Display Aberrant Characteristics in ALS Mutant Cells.

Figure 7

(A) Model of the relationships among normally functioning, dynamic RNPs, transient SGs, and permanent pathological protein inclusions.

(B) Schematic showing that neuronal SGs are diverse and contain proteins involved in protein quality control pathways.

(C) Schematic showing altered SG dynamics, composition, and subcellular distribution in ALS mutant motor neurons.