Table 1.
Participant Demographics, Medical History and Unadjusted Renal Parameters in Hormone Therapy Users and Non-users.
| Characteristica | HT users (n=574) | HT non-users (n=1462) | p-value |
|---|---|---|---|
| Age, mean (SD) | 60.6 (7.5) | 63.3 (8.8) | <0.001b |
|
| |||
| Race, n(%) | <0.001c | ||
| Non-Hispanic White | 255 (44.4%) | 253 (17.3%) | |
| Hispanic | 80 (13.9%) | 488 (33.4%) | |
| Non-Hispanic Black | 239 (41.6%) | 721 (49.3%) | |
|
| |||
| Education, n(%) | <0.001c | ||
| Less than High School | 66 (11.5%) | 441 (30.1%) | |
| Partial High School | 23 (4.0%) | 63 (4.3%) | |
| High School Graduate/GED | 204 (35.6%) | 396 (27.1%) | |
| Post High School Education | 281 (49.9%) | 562 (38.4%) | |
|
| |||
| Smoking, n(%) | 202 (35.2%) | 417 (28.5%) | 0.004c |
|
| |||
| Hypertension, n(%) | 442 (77.1%) | 1114 (76.3%) | 0.73c |
|
| |||
| Diabetes, n(%) | 117 (20.4%) | 610 (41.7%) | <0.001c |
|
| |||
| BMI | 30.6 (26.4,35.3) | 31.7 (27.7, 36.6) | <0.001d |
|
| |||
| Surgical Menopause, n(%) | 330 (69.1%) | 456 (45.9%) | <0.001c |
|
| |||
| Age at menopause, median (IQR) | 45 (39-50) | 47 (40-51) | <0.001d |
|
| |||
| Total cholesterol (mg/dl) | 202.2 (175.9, 228) | 200.5 (175,229.6) | 0.93d |
|
| |||
| LDL (mg/dl) | 112.8 (90.7, 140.1) | 123.5 (97.0, 149.3) | <0.001d |
|
| |||
| Triglycerides (mg/dl) | 138.5 (95, 193) | 123 (89, 175.6) | <0.001d |
|
| |||
| HDL (md/dl) | 57.8 (49.9, 70.6) | 52.3 (43.5, 62.8) | <0.001d |
|
| |||
| HTN in either parent, n(%) | 445 (77.5%) | 1011 (69.1%) | <0.001c |
|
| |||
| Diabetes in either parent, n(%) | 170 (35.6%) | 347 (35.0%) | 0.86c |
|
| |||
| UACR (mg/g Cr) | 3.3 (1.5, 6.7) | 5.2 (2.2, 16.2) | <0.001d |
|
| |||
| UACR >25 mg/g Cr, n(%) | 53 (9.2%) | 287 (19.0%) | <0.001c |
|
| |||
| Cr (mg/dl) | 0.75 (0.66, 0.86) | 0.75 (0.65, 0.89) | 0.28d |
|
| |||
| eGFR (ml/min/1.73m2) | 91.4 (78.5, 101.7) | 89.7 (74.2, 101.5) | 0.05d |
|
| |||
| eGFR< 60 ml/min/1.73m2, n(%) | 35 (6.1%) | 156 (10.7%) | 0.001c |
Abbreviations: GED = General Education Diploma, HT = hormone therapy, BMI = body-mass index, HDL = high density lipoprotein, LDL = low density lipoprotein, HTN = hypertension, UACR = urinary albumin-to-creatinine ratio, Cr = creatinine, eGFR = estimated glomerular filtration rate, BSA = body-surface area.
a
All data presented as n(%) and median (interquartile range) unless otherwise specified.
b
Student's t-test as variable was normally distributed.
c
Fisher's Exact Test
d
Wilcoxon Rank Sum.