Table 2.
Unadjusted analysis of risk factors for postoperative delirium.
| Relative risk | 95% CI | p | |
|---|---|---|---|
| Age (per 1 year increase) | |||
| Age ≤ 50 | 1.12 | 1.01, 1.25 | 0.028 |
| Age > 50 | 0.91 | 0.85, 0.96 | 0.001 |
| Male gender | 0.93 | 0.60, 1.44 | 0.74 |
| Caucasian race | 0.80 | 0.46, 1.41 | 0.45 |
| History of anxiety | 1.29 | 0.86, 1.95 | 0.22 |
| History of depression | 1.26 | 0.83, 1.92 | 0.28 |
| Native lung disease | |||
| COPD | Reference | ||
| CF/Non-CF bronchiectasis | 0.79 | 0.39, 1.63 | 0.53 |
| Interstitial lung disease | 0.66 | 0.41, 1.07 | 0.09 |
| Other | 1.20 | 0.68, 2.13 | 0.53 |
| Pre-transplant medications | |||
| Corticosteroids | 0.97 | 0.64, 1.48 | 0.90 |
| Immunosuppressants | 1.10 | 0.62, 1.97 | 0.74 |
| Opiates | 0.89 | 0.47, 1.70 | 0.73 |
| Antidepressants | 1.01 | 0.64, 1.58 | 0.98 |
| Benzodiazepines | 1.38 | 0.91, 2.09 | 0.125 |
| Lung allocation score (per 1 point increase) | 1.00 | 0.99, 1.02 | 0.46 |
| Body mass index (per 1 kg/m2 increase) | 1.01 | 0.96, 1.05 | 0.82 |
| Cardiopulmonary bypass | 1.76 | 1.19, 2.62 | 0.005 |
| Bilateral Transplant | 1.70 | 1.06, 2.72 | 0.027 |
| Duration of the operation (per 30 minute increase) | 1.08 | 1.03, 1.14 | 0.005 |
| Total ischemic time (per 30 minute increase) | 1.10 | 1.03, 1.18 | 0.008 |
| Minutes with MAP <60mmHg (per 15 minute increase) | 1.09 | 1.03, 1.15 | 0.004 |
| Minutes with CPP <50mmHg (per 15 minute increase) | 1.06 | 1.01, 1.10 | 0.009 |
| Postoperative benzodiazepine treatment | 1.79 | 1.16, 2.74 | 0.008 |
| Grade 3 PGD | 2.25 | 1.46, 3.48 | <0.001 |
Abbreviations: COPD = chronic obstructive pulmonary disease; CF = cystic fibrosis; MAP = mean arterial pressure; CPP = cerebral perfusion pressure; PGD = primary graft dysfunction