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. Author manuscript; available in PMC: 2019 May 25.
Published in final edited form as: Circ Res. 2018 Mar 7;122(11):1565–1575. doi: 10.1161/CIRCRESAHA.118.312821

Table 2.

Linear Regression Model for Predictors of CPC Subsets

Variable CD34+ CD34+/CD133+ CD34+/CXCR4+ CD34+/VEGF+
% Change (95% CI) P Value % Change (95% CI) P Value % Change (95% CI) P Value % Change (95% CI) P Value
Age (per 10-y increase) −9.8 (−12.3 to −7.1) <0.001 −11.9 (−14.7 to −9.1) <0.001 −8.2 (−11.2 to −5.2) <0.001 −0.5 (−11.7 to 12.1) 0.94
Body mass index (per 5-U increase) 6.1 (3.4 to 8.9) <0.001 8 (4.9 to 11.2) <0.001 3.6 (0.5 to 6.7) 0.02 −13 (−22 to −3.1) 0.01
GFR (per 10-U increase) 0.1 (−1.1 to 1.4) 0.85 −0.5 (−1.9 to 0.9) 0.50 0 (−1.4 to 1.5) 0.95 −6.9 (−11.8 to −1.7) 0.01
Male 12.2 (5.2 to 19.5) <0.001 9.3 (1.7 to 17.5) 0.02 11.4 (3.5 to 20) 0.004 3.3 (−21.1 to 35) 0.82
Black −11.7 (−18 to −5) 0.001 −9.1 (−16.3 to −1.1) 0.03 −6.9 (−14.5 to 1.4) 0.10 −15 (−37.7 to 16.1) 0.31
Hypertension 5.4 (−3.9 to 15.7) 0.26 3.8 (−6.6 to 15.3) 0.49 3.8 (−6.9 to 15.6) 0.50 82.2 (23.1 to 169.9) 0.003
Former or current smoking 3.8 (−2.5 to 10.4) 0.24 6.3 (−0.9 to 14) 0.09 7.7 (0.2 to 15.7) 0.04 −11.6 (−31.9 to 14.9) 0.36
Diabetes mellitus 2 (−4.2 to 8.7) 0.54 4.5 (−2.7 to 12.2) 0.23 4.1 (−3.2 to 12) 0.28 3.5 (−20.6 to 34.7) 0.80
Hyperlipidemia 3.7 (−3.9 to 11.9) 0.35 3.8 (−4.8 to 13.1) 0.40 6.2 (−2.8 to 16) 0.18 −9.1 (−34 to 25.4) 0.56
Acute myocardial infarction 19.2 (7.5 to 32.2) 0.001 24.6 (10.7 to 40.2) <0.001 27.8 (13.2 to 44.2) <0.001 141.6 (55.7 to274.3) <0.001

CI indicates confidence interval; CXCR4, chemokine (C-X-C motif) receptor 4; GFR, glomerular filtration rate; and VEGFR, vascular endothelial growth factor receptor.