Table 5.
Age | YSM | BMI | Baseline femur marrow fat | Baseline spine marrow fat | Change in femur marrow fat | Change in spine marrow fat | 25-OHD | E2 | FSH | PTH | PINP | CTX | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DE Baseline values | |||||||||||||
Femur Neck | |||||||||||||
Total vBMD (mg/cm3) | −0.26‡ | −0.21† | −0.11 | −0.33‡ | −0.06 | 0.14 | −0.02 | −0.06 | −0.01 | −0.03 | −0.06 | 0.12 | 0.02 |
Cortical vBMD (mg/cm3) | −0.07 | −0.10 | −0.22† | −0.04 | 0.00 | 0.20† | −0.01 | −0.00 | −0.06 | −0.08 | −0.10 | 0.02 | −0.00 |
Trabecular vBMD (mg/cm3) | −0.32‡ | −0.27‡ | −0.09 | −0.47‡ | −0.15* | 0.13 | 0.04 | −0.05 | −0.06 | 0.07 | −0.00 | 0.16* | 0.07 |
Marrow fat (mg/cm3) | 0.19† | 0.12 | −0.07 | -- | 0.17* | −0.38‡ | −0.08 | 0.12 | 0.00 | −0.03 | −0.09 | −0.05 | −0.07 |
Lumbar spine | |||||||||||||
Trabecular vBMD (mg/cm3) | −0.29‡ | −0.32‡ | −0.10 | −0.29‡ | −0.56‡ | 0.07 | 0.15 | −0.02 | −0.07 | 0.16* | 0.11 | 0.07 | 0.04 |
Marrow fat (mg/cm3) | 0.21† | 0.32‡ | 0.25‡ | 0.17* | -- | −0.01 | −0.42‡ | 0.04 | 0.12 | −0.10 | −0.10 | −0.01 | −0.03 |
DE Annualized rates of change | |||||||||||||
Femur Neck | |||||||||||||
Total vBMD (mg/cm3) | 0.07 | 0.20* | 0.16* | 0.13 | 0.16* | −0.05 | −0.05 | −0.07 | 0.15 | 0.00 | −0.05 | 0.09 | −0.05 |
Cortical vBMD (mg/cm3) | 0.15 | 0.15 | 0.06 | 0.09 | 0.13 | 0.02 | −0.10 | 0.02 | 0.08 | 0.07 | −0.06 | −0.09 | −0.13 |
Trabecular vBMD (mg/cm3) | 0.05 | 0.10 | 0.16* | 0.04 | 0.14 | −0.07 | −0.07 | −0.08 | 0.10 | 0.02 | −0.00 | 0.17* | 0.06 |
Marrow fat (units) | −0.09 | −0.19* | −0.18* | −0.38‡ | −0.01 | -- | 0.14 | 0.03 | −0.22† | 0.16* | −0.01 | 0.06 | 0.13 |
Lumbar spine | |||||||||||||
Trabecular vBMD (mg/cm3) | −0.00 | 0.09 | 0.05 | 0.14 | 0.10 | −0.19* | −0.07 | 0.00 | 0.09 | −0.03 | −0.00 | −0.07 | −0.13 |
Marrow fat (mg/cm3) | −0.05 | −0.00 | −0.13 | −0.08 | −0.42‡ | 0.14 | -- | 0.04 | −0.09 | 0.02 | 0.05 | 0.11 | 0.13 |
<0.05,
<0.01,
<0.001.