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. 2018 May 25;8:8107. doi: 10.1038/s41598-018-26453-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of LDLR and PCSK9 rare variants on LDL-C levels and onset age of MI. Dots represent the change from non-carriers of LDLR/PCSK9 rare variants for each group and lines indicate the 95% confidence interval. Effects were estimated using multiple linear regression models adjusted for age, gender, BMI, smoking status and cholesterol lowering medications in assessing LDL cholesterol levels, and controlling for the same parameters except age in assessing onset age of MI. Abbreviations: r: Pearson’s correlation coefficient.