Table 1.
Baseline characteristics of study participants in the discovery and replication stages.
| Stage | Phenotype | N | Mean Age (SD) | Mean onset-age of MI (SD) | Source | Male (%) | Smoking (%) | MeanBMI (SD) | Mean systolic BP (mmHg) (SD) | Mean LDL-C (mg/dL) (SD) | Mean HDL-C (mg/dL) (SD) | Mean TG (mg/dL) (SD) | Mean HbA1c(%)(SD) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Discovery | Cases | 2,775 | 62.7(10.9) | 57.6(10.8) | BBJ | 84.5 | 74.2 | 24.2 (3.4) | 126.8 (16.4) | 111.8 (31.8) | 47.5 (12.6) | 156.2 (110.5) | 6.63 (1.59) |
| Controls | 2,965 | 56.4(12.1) | — | PSC(N = 963) | 61.0 | NA | NA | NA | NA | NA | NA | NA | |
| MRC(N = 1,060) | 74.4 | 54.7 | 23.6 (3.2) | 130.9 (17.9) | NA | NA | NA | NA | |||||
| Univ. of Tokyo(N = 942) | 64.6 | 41.2 | 22.4 (3.9) | 114.8 (23.4) | 125.7 (46.6) | 65.6 (17.4) | 113.8 (70.4) | 5.72 (0.85) | |||||
| Replication | Cases | 7,181 | 68.0(9.8) | 62.2(10.4) | BBJ | 80.9 | 72.0 | 23.8 (3.3) | 129.3 (16.9) | 111.6 (31.6) | 48.9 (14.6) | 147.5 (93.7) | 6.40 (1.45) |
| Controls | 5,408 | 62.8(9.8) | — | BBJ | 53.4 | 59.6 | 22.4 (3.8) | 128.8 (17.0) | 119.2 (34.7) | 57.5 (17.0) | 132.0 (94.8) | 6.16 (1.37) |
In controls in the discovery stage, blood test data were available only from University of Tokyo samples. Abbreviations: BBJ, Biobank Japan project; PSC, Pharma SNP consortium; Univ. of Tokyo, The University of Tokyo Hospital; SD, standard deviation; T-Chol, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; and NA, blood test data not available.