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. 2018 May 25;8:8096. doi: 10.1038/s41598-018-25903-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representing where HTT PTMs and HTT missense SNPs intersect. (A) Linear map of HTT SNPs leading to missense mutations mapped to known HTT PTMs. The two missense mutations that directly intersect with myristoylation at G553 and phosphorylation at S2076, G553E and S2076P, are boxed. (B) PTMs within the first 586 amino acids of HTT are highlighted. Proteolytic caspase sites are indicated on the bottom while non-caspase mediated proteolytic sites are displayed on top. G553 is myristoylated following caspase cleavage at D552.