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. 2018 May 25;8:8096. doi: 10.1038/s41598-018-25903-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Allelic representation of the compound effect of the G553E mutation with the HD mutation. HD is a monogenic disease caused by a CAG expansion. The SNP encoding the G553E mutation occurs on the control allele causing toxicity. It is predicted that carriers of both mutations with have an earlier onset of disease.