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. 2018 May 25;8:8101. doi: 10.1038/s41598-018-26387-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intravenous (i.v.) pharmacokinetics of PMX53 and PMX205 in wild-type mice: Complement C5a receptor 1 antagonists PMX53 (red graph lines) and PMX205 (blue graph lines) concentration vs time profile in plasma (A), brain (B) and spinal cord (C) following single i.v. bolus drug dose of 1 mg/kg of either antagonist in mice at time = 0. Data points represent mean ± SEM of n = 4 mice at each time point.